I’m sure you know the difference in meaning between these two words, but I see the wrong one written so frequently that I thought I might as well harangue you today:
LOSE means to misplace, be deprived of or cease to retain something. It rhymes with FUSE, MUSE and WOOS.
LOOSE is the opposite of tight. It rhymes with CABOOSE, GOOSE and JUICE. (Who said English spelling isn’t idiosyncratic?)
If you type one of these words, look at it carefully to be certain you have the word you want. That’s called proofreading; don’t just look to see that you spelled the word correctly. Determine that even though it is spelled right it is the word you need.